Top Nattokinase Brands In 2025
Not all nattokinase is created equal. Here are the top brands of nattokinase out there and why one beats out the rest.
Our Criteria:
- Clinically Relevant Developed Dose (10,800 FU) based off of this 12 month study of 1k+ participants.
- Includes supporting ingredients like vitamin K2 or selenium (for spike protein) to increase effectiveness.
- Company mentions that they are third party tested
- Shares third party testing results directly on site.
- Has positive reviews and a positive brand image
- The price per clinically relevant serving + vitamin k2 (a critical supportive ingredient) is less than $2/day
- Has a money back guarantee
- Is in the best bioavailable format with easy consumption
- Doesn't contain maltodextrin (though often hidden on supplement labels)
- Company has strong education on site
What to look for in a nattokinase supplement:
Here's What's Important:
Look for products that deliver at least 10,800 FU (fibrinolytic units) per serving. Research shows that this higher enzyme activity is where real circulatory support begins.
Vitamin K2 plays a vital role in maintaining vascular flexibility and ensuring calcium goes to your bones, not your arteries. It’s an essential partner to nattokinase for healthy circulation.
Nattokinase works best when paired with compounds that target inflammation and lipid balance — such as oat beta glucan or other natural fibers that complement enzyme activity.
Powdered formulas dissolve easily, making them more bioavailable and far easier to take consistently than capsules. Plus, powders allow for full clinical doses that wouldn’t fit in a capsule.
Always choose a product that’s independently verified for enzyme activity, purity, and safety.
Here's What To Avoid:
Most nattokinase supplements stop at 2,000–4,000 FU which is far below the levels shown in research to make a measurable difference in circulation. For real results, look for 10,000 FU or more per serving.
Nattokinase works best when paired with supportive compounds that help maintain blood vessel health and manage inflammation. Avoid basic capsules that skip critical partners like Vitamin K2 and Oat Beta Glucan.
Powders absorb faster and more completely than capsules — and are easier to take daily. Capsules often use fillers, which are not mentioned on label, and can’t physically fit potent, research-level doses.
Many brands list “nattokinase” without proving it’s active. If there’s no third-party testing on site verifying enzyme potency (measured in FU), assume the enzyme has degraded or isn’t doing much at all.
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This is an advertisement for Toku Health and is intended for informational purposes only. All information provided by Toku Health does not constitute medical advice and should not be used as a replacement for your doctor's advice. Please consult your doctor regarding any change in treatment or supplementation.
* These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Top Nattokinase Supplements 2025
#1 Toku Health
One of the only brands currently offering a clinically relevant dose of Nattokinase (10,800 FU) based off of a 12 month study with 1k+ participants.
Toku Flow isn’t a single-ingredient capsule, it’s a full-spectrum circulation formula with Vitamin K2 to support vascular elasticity and Beta Glucan to promote cholesterol balance.
Toku Flow is tested for enzyme activity, purity, and heavy metals. You can find those results clearly published on their site unlike many brands out there.
Powdered formulas dissolve easily, making them more bioavailable and easier to stay consistent.
Toku uses chickpeas during fermentation to offer the same benefits without the possible allergens.
#2 Double Wood
Double Wood publicly shares third party testing on site
Cost per a clinically relevant dose plus Vitamin K2 will be less than $2.
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules + 2 additional capsules of Vitamin K2.
Powdered formulas dissolve easily, making them more bioavailable and easier to stay consistent.
per clinically relevant dose of nattokinase + vitamin k2
#3 Luma Nutrition
Claims third party testing, though doesn't share the results directly on site.
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules + 2 additional capsules of Vitamin K2.
Powdered formulas dissolve easily, making them more bioavailable and easier to stay consistent.
❌ High Cost/Clinically Relevant Serving
per clinically relevant dose of nattokinase + vitamin k2
#4 TWC Spike Support
This is a decent option for spike protein detoxing as it includes other ingredients, but it still does not have a clinically relevant dose of nattokinase.
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules.
Company claims that third party tested has taken place but will not share results when contacted. Considered "proprietary information and cannot be shared publicly."
❌ High Cost/Clinically Relevant Serving
per clinically relevant dose of nattokinase
#5 Natural Factors
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules.
Does not contain additional supporting ingredients like Vitamin K2 and Oat Beta Glucan
❌ High Cost/Clinically Relevant Serving
❌ No Mention of Third Party Testing On Site
per clinically relevant dose of nattokinase + vitamin k2
#6 Doctor's Best
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules.
Does not contain additional supporting ingredients like Vitamin K2 and Oat Beta Glucan
❌ Contains Filler: Maltodextrin
❌ No Mention of Third Party Testing On Site
per clinically relevant dose of nattokinase + vitamin k2
Let's Break Down The Cost
For this same clinically effective dose, you'd need to take 8 capsules across all of the other top nattokinase brands, many at a much higher cost/clinically effective serving.
Total Cost
6 Nattokinase Capsule (Clinically Relevant Dose)
6 Nattokinase Capsule (Clinically Relevant Dose)
6 Nattokinase Capsule (Clinically Relevant Dose)
6 Nattokinase Capsule (Clinically Relevant Dose)
6 Nattokinase Capsule (Clinically Relevant Dose)
1 drink
As little as $1.59/day
#1 Toku Flow
#2 Double Wood
2 Vitamin K2
8 pills
$1.66/day
2 Vitamin K2
2 Vitamin K2
2 Vitamin K2
8 pills
$2.91/day
8 pills
$3.86/day
6 pills
$2.92/day
8 pills
$1.66/day
#3 Luma Nutrition
#4 Natural Factors
#5 Spike Support
#6 Doctor's Best
First, What Is Nattokinase?
But the truth is...
Parting Thoughts
Shop Toku Flow, the best nattokinase on the market, and use code THEBEST for 10% off.
#1 Toku Health
One of the only brands currently offering a clinically relevant dose of Nattokinase (10,800 FU) based off of a 12 month study with 1k+ participants.
Toku Flow isn’t a single-ingredient capsule, it’s a full-spectrum circulation formula with Vitamin K2 to support vascular elasticity and Beta Glucan to promote cholesterol balance.
Toku Flow is tested for enzyme activity, purity, and heavy metals. You can find those results clearly published on their site unlike many brands out there.
Powdered formulas dissolve easily, making them more bioavailable and easier to stay consistent.
Toku uses chickpeas during fermentation to offer the same benefits without the possible allergens.
per clinically relevant dose of nattokinase + vitamin k2
#2 Double Wood
Double Wood publicly shares third party testing on site
Cost per a clinically relevant dose plus Vitamin K2 is less than $2.
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules + 2 additional capsules of Vitamin K2.
Does not contain additional supporting ingredients like Vitamin K2 and Oat Beta Glucan
per clinically relevant dose of nattokinase + vitamin k2
#3 Luma Nutrition
Claims third party testing, though doesn't share the results directly on site.
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules + 2 additional capsules of Vitamin K2.
Does not contain additional supporting ingredients like Vitamin K2 and Oat Beta Glucan
per clinically relevant dose of nattokinase + vitamin k2
Let's Break Down The Cost
For this same clinically effective dose, you'd need to take 8 capsules across all of the other top nattokinase brands, many at a much higher cost/clinically effective serving.
1 drink
As little as $1.59/day
Total Cost
#1 Toku Flow
8 pills
$1.66/day
2 Vitamin K2
6 Nattokinase Capsule (Clinically Relevant Dose)
#2 Double Wood
8 pills
$2.91/day
2 Vitamin K2
6 Nattokinase Capsule (Clinically Relevant Dose)
#3 Luma Nutrition
8 pills
$3.86/day
2 Vitamin K2
6 Nattokinase Capsule (Clinically Relevant Dose)
#4 Natural Factors
6 pills
$2.92/day
6 Nattokinase Capsule (Clinically Relevant Dose)
#5 Spike Support
8 pills
$1.66/day
2 Vitamin K2
6 Nattokinase Capsule (Clinically Relevant Dose)
#6 Doctor's Best
#4 TWC Spike Support
This is a decent option for spike protein detoxing as it includes other ingredients, but it still does not have a clinically relevant dose of nattokinase.
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules + 2 additional capsules of Vitamin K2.
Company claims that third party tested has taken place but will not share results when contacted. Considered "proprietary information and cannot be shared publicly."
per clinically relevant dose of nattokinase + vitamin k2
#5 Natural Factors
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules + 2 additional capsules of Vitamin K2.
Does not contain additional supporting ingredients like Vitamin K2 and Oat Beta Glucan
per clinically relevant dose of nattokinase + vitamin k2
#6 Doctor's Best
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules + 2 additional capsules of Vitamin K2.
Does not contain additional supporting ingredients like Vitamin K2 and Oat Beta Glucan
per clinically relevant dose of nattokinase + vitamin k2
Our Criteria:
We ranked each brand on a scale of 1 to 10 with the following criteria below. Each criteria is ranked as one point each to reach a total ranking out of 10 points:
- Clinically Relevant Developed Dose (10,800 FU) based off of this 12 month study of 1k+ participants.
- Includes supporting ingredients like vitamin K2 or selenium (for spike protein) to increase effectiveness.
- Company mentions that they are third party tested
- Shares third party testing results directly on site.
- Has positive reviews and a positive brand image
- The price per clinically relevant serving + vitamin k2 (a critical supportive ingredient) is less than $2/day
- Has a money back guarantee
- Is in the best bioavailable format with easy consumption
- Doesn't contain maltodextrin (though often hidden on supplement labels)
- Company has strong education on site
Parting Thoughts
A high-quality nattokinase supplement should balance the right formulation, effective support ingredients, and an experience that fits your routine (or something you’ll actually enjoy taking).
Shop Toku Flow, the best nattokinase on the market, and use code THEBEST for 10% off.
