5 Reasons Nattokinase Is Used to Support Heart Health
Discover why nattokinase supports circulation and cardiovascular wellness through clinical research
Hearth Health Backed By Clinical Research
Nattokinase has been examined in long-term clinical research focused on cardiovascular structure and blood flow related markers.
In a 12-month study involving over 1,000 participants, when taking at 10,800 FU daily, nattokinase supplementation was associated with a:
39.1% improvement in coronary plaque health (measured by coronary plaque score)
25% improvement in carotid artery flexibility (measured by CCA-IMT)
17.6% reduction in total cholesterol
16.5% reduction in triglycerides
Nattokinase Goes Beyond Just Cholesterol
Cholesterol is only one part of the heart health picture.
A more complete cardiovascular assessment often includes markers related to:
ApoB, which reflects the number of circulating lipoprotein particles
Blood viscosity and flow characteristics
Vascular inflammation and endothelial function
Overall circulatory efficiency
A Clinically Relevant Dose of Nattokinase
Not all nattokinase is created equal. In fact, many brands on the market are underdosed and not third party tested. Explore a high-potency nattokinase at 10,800 FU that is third party tested, free of fillers, and soy free.
A Natural, Food-Derived Approach to Heart Health
Nattokinase was originally discovered in natto, a fermented Japanese food that has been part of traditional diets for over a thousand years.
Populations with regular natto consumption have long been associated with strong cardiovascular health, which led researchers to identify nattokinase as one of its most compelling enzymes.
Toku Flow offers a modern, convenient way to incorporate this Japanese enzyme into a daily routine without needing to consume natto itself.
Why this matters:
Some of the most trusted heart-supporting ingredients come from traditional foods, not synthetic trends.
Supports the Systems That Influence Blood Pressure
Blood pressure is shaped by multiple factors, including circulation, vascular tone, and arterial flexibility.
Nattokinase has been explored in research examining how it supports the underlying circulatory systems that influence healthy blood pressure levels already within the normal range, rather than acting as a direct or immediate intervention.
Designed for Long-Term, Daily Heart Support
Heart health is not built in weeks. It’s shaped by daily habits over years.
Nattokinase is non-stimulatory and commonly used in long-term wellness routines focused on consistent cardiovascular support rather than noticeable short-term effects.
We Ranked Nattokinase Supplements from Best To Worst.
Here are our top 3 recommended:
#1 Toku Health
✅ Highest Potency Available
One of the only brands currently offering a clinically relevant dose of Nattokinase (10,800 FU) based off of a 12 month study with 1k+ participants.
✅ Adds Vitamin K2 & Beta Glucan
Toku Flow isn’t a single-ingredient capsule, it’s a full-spectrum circulation formula with Vitamin K2 to support vascular elasticity and Beta Glucan to promote cholesterol balance.
✅ Published Third Party Testing
Toku Flow is tested for enzyme activity, purity, and heavy metals. You can find those results clearly published on their site unlike many brands out there.
✅ Best Bioavailable Format
Powdered formulas dissolve easily, making them more bioavailable and easier to stay consistent.
✅ BONUS: Soy Free
Toku uses chickpeas during fermentation to offer the same benefits without the possible allergens.
#2 Double Wood
✅ Published Third Party Testing
Double Wood publicly shares third party testing on site
✅ More Affordable Capsule Option
Cost per a clinically relevant dose plus Vitamin K2 will be less than $2.
❌ Not A Clinically Relevant Dose
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules + 2 additional capsules of Vitamin K2.
❌ Nattokinase Only Capsule
Powdered formulas dissolve easily, making them more bioavailable and easier to stay consistent.
#3 Luma Nutrition
✅ Third Party Tested
Claims third party testing, though doesn't share the results directly on site.
✅ Money Back Guarantee
❌ Not A Clinically Relevant Dose
Current dose is 2,000 FU per capsule, which means in order to get a clinically relevant dose, you need to take 6 capsules + 2 additional capsules of Vitamin K2.
❌ Nattokinase Only Capsule
Powdered formulas dissolve easily, making them more bioavailable and easier to stay consistent.
❌ High Cost/Clinically Relevant Serving
